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Rubiginosin B selectively inhibits Treg cell differentiation and enhances anti-tumor immune responses by targeting calcineurin-NFAT signaling pathway Journal article
Geng,Chang An, Chen,Feng Yang, Zheng,Jing Bin, Liao,Ping, Li,Tian Ze, Zhang,Xue Mei, Chen,Xin*, Chen,Ji Jun. Rubiginosin B selectively inhibits Treg cell differentiation and enhances anti-tumor immune responses by targeting calcineurin-NFAT signaling pathway[J]. Phytomedicine, 2023, 116, 154898.
Authors:  Geng,Chang An;  Chen,Feng Yang;  Zheng,Jing Bin;  Liao,Ping;  Li,Tian Ze; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:6.7/6.2 | Submit date：2023/08/03
Calcineurin  cd4+foxp3+ Regulatory t Cells (Tregs)  Nuclear Factor Of Activated t Cells (Nfat)  Rhododendron Brachypodum  Rubiginosin b (Rgb)  Tumor Microenvironment  
Anti-TNFR2 enhanced the antitumor activity of a new HMGN1/3M-052 stimulated dendritic cell vaccine in a mouse model of colon cancer Journal article
Zhu, Lan, Zhang, Xiangyan, Chen, Xin, Yang, De, Nie, Yujie, Pan, Runsang, Li, Linzhao, Wang, Chenglv, Gui, Huan, Chen, Shuanghui, Jing, Qianyu, Wang, Mengjiao, Nie, Yingjie. Anti-TNFR2 enhanced the antitumor activity of a new HMGN1/3M-052 stimulated dendritic cell vaccine in a mouse model of colon cancer[J]. Biochemical and Biophysical Research Communications, 2023, 653, 106-114.
Authors:  Zhu, Lan;  Zhang, Xiangyan;  Chen, Xin;  Yang, De;  Nie, Yujie; et al.
Favorite | TC[WOS]:6 TC[Scopus]:5  IF:2.5/2.7 | Submit date：2023/05/02
Anti-tnfr2  Antitumor  cd4+foxp3+regulatory t Cells (Tregs)  Dendritic Cells (Dcs)  Hmgn1 And 3m-052  Immunotherapy  
Exosome-Modified Liposomes Targeted Delivery of Thalidomide to Regulate Treg Cells for Antitumor Immunotherapy Journal article
Yang,Yang, Wang,Qingfu, Zou,Huimin, Chou Chon-Kit, Chen Xin*. Exosome-Modified Liposomes Targeted Delivery of Thalidomide to Regulate Treg Cells for Antitumor Immunotherapy[J]. Pharmaceutics, 2023, 15(4), 1074.
Authors:  Yang,Yang;  Wang,Qingfu;  Zou,Huimin;  Chou Chon-Kit;  Chen Xin*
Favorite | TC[WOS]:5 TC[Scopus]:5  IF:4.9/5.5 | Submit date：2023/08/03
Exosome  Regulatory t Cells (Tregs)  Thalidomide  Tnfr2  
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells Journal article
He, Tianzhen, Chen, Yibo, Yang, De, Islam, Md Sahidul, Chou, Chon Kit, Liu, Jiarui, Faustman, Denise L., Oppenheim, Joost J., Chen, Xin*. TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells[J]. Cellular Oncology, 2022, 46(1), 167-177.
Authors:  He, Tianzhen;  Chen, Yibo;  Yang, De;  Islam, Md Sahidul;  Chou, Chon Kit; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:4.9/5.2 | Submit date：2023/01/30
cd4+foxp3+ Regulatory t Cells (Tregs)  Cell Death  Lymphoma  Tnfr2  Tnfr2 Antagonistic Antibody  
A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer Journal article
Jiang, Mengmeng, Liu, Jia, Yang, De, Tross, Debra, Li, Ping, Chen, Fengyang, Alam, Md Masud, Faustman, Denise L., Oppenheim, Joost J., Chen, Xin. A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer[J]. International Immunopharmacology, 2021, 101, 108345.
Authors:  Jiang, Mengmeng;  Liu, Jia;  Yang, De;  Tross, Debra;  Li, Ping; et al.
Favorite | TC[WOS]:22 TC[Scopus]:22  IF:4.8/5.0 | Submit date：2021/12/08
Antitumor  cd4+foxp3+ Regulatory t Cells (Tregs)  Hmgn1 And R848  Immunotherapy  Tnfr2  
Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis Journal article
Ye, L., Peng, W., Niu, Y., Xiang, X., Wei, X., Wang, Z., Wang, X., Zhang, Z., Chen, X.*, Zhou, Q.. Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis[J]. ANNALS OF TRANSLATIONAL MEDICINE, 2020, 1647-1647.
Authors:  Ye, L.;  Peng, W.;  Niu, Y.;  Xiang, X.;  Wei, X.; et al.
Favorite |  | Submit date：2022/08/30
Tumor Necrosis Factor Receptor Type 2 (Tnfr2)  Regulatory t Cells (Tregs)  Malignant Pleural Effusion (Mpe)  
Preferential Expansion of CD4+Foxp3+ Regulatory T Cells (Tregs) In Vitro by Tumor Necrosis Factor Book chapter
出自: T-Cell Receptor Signaling:Humana, New York, NY, 2020, 页码:71-78
Authors:  Chon-Kit Chou;  Xin Chen
Favorite | TC[WOS]:1 TC[Scopus]:1 | Submit date：2021/03/01
Cd4++++ Foxp3++++ Regulatory t Cells (Tregs)  Cfse Cell Division Assay  Flow Cytometry  Selective Expansion  Tnf Receptor 2 (Tnfr2)  Tumor Necrosis Factor (Tnf)  
In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo. Journal article
Zhou, Q., Hu, Y., Howard, O., Oppenheim, J., Chen, X.. In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.[J]. Cytokine, 2014, 56-64.
Authors:  Zhou, Q.;  Hu, Y.;  Howard, O.;  Oppenheim, J.;  Chen, X.
Favorite |   IF:3.7/3.5 | Submit date：2022/08/30
FoxP3  IL-2  KI  KO  Regulatory T cell  TNF  TNFR2  TNFR2 Fc fusion protein  TNFR2-Fc  Teffs  Th17  Tregs  effector T cells  forkhead box P3  knock in  knock out  nCD4  naïve CD4 cells  regulatory T cells  tumor necrosis factor receptor type II  
Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity Journal article
Xin Chen, Joost J. Oppenheim. Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity[J]. FEBS LETTERS, 2011, 585(23), 3611-3618.
Authors:  Xin Chen;  Joost J. Oppenheim
Favorite | TC[WOS]:81 TC[Scopus]:84  IF:3.0/3.8 | Submit date：2019/01/14
Tnf  Tnfr2  Regulatory t Cells (Tregs)  Effector t Cells (Teffs)