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SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1 Journal article
Dong, Fangyuan, He, Kang, Zhang, Shan, Song, Kaiyuan, Jiang, Luju, Hu, Li Peng, Li, Qing, Zhang, Xue Li, Zhang, Naiqi, Li, Bo Tai, Zhu, Li Li, Li, Jun, Feng, Mingxuan, Gao, Yunchen, Chen, Jie, Hu, Xiaona, Wang, Jiaofeng, Jiang, Chongyi, Wang, Cun, Zhu, Helen He, Da, Lin Tai, Ji, Jianguang, Zhang, Zhi Gang, Bao, Zhijun, Jiang, Shu Heng. SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1[J]. Cell Reports, 2024, 43(10), 114818.
Authors:  Dong, Fangyuan;  He, Kang;  Zhang, Shan;  Song, Kaiyuan;  Jiang, Luju; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:7.5/8.5 | Submit date：2024/11/05
Aerobic Glycolysis  Drug Discovery  Drug Repurposing  Sert  Slc6a4  
Drug–Target Interaction Prediction Based on an Interactive Inference Network Journal article
Chen, Yuqi, Liang, Xiaomin, Du, Wei, Liang, Yanchun, Wong, Garry, Chen, Liang. Drug–Target Interaction Prediction Based on an Interactive Inference Network[J]. International Journal of Molecular Sciences, 2024, 25(14), 7753.
Authors:  Chen, Yuqi;  Liang, Xiaomin;  Du, Wei;  Liang, Yanchun;  Wong, Garry; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:4.9/5.6 | Submit date：2024/09/03
Convolutional Neural Network  Drug Repurposing  Dti  Interactive Inference Network  Self-attention  
Repurposing sodium stibogluconate as an uracil DNA glycosylase inhibitor against prostate cancer using a time-resolved oligonucleotide-based drug screening platform Journal article
Nao, Sang Cuo, Huang, Le Sheng, Shiu-Hin Chan, Daniel, Wang, Xueliang, Li, Guo Dong, Wu, Jia, Wong, Chun Yuen, Wang, Wanhe, Leung, Chung Hang. Repurposing sodium stibogluconate as an uracil DNA glycosylase inhibitor against prostate cancer using a time-resolved oligonucleotide-based drug screening platform[J]. Bioorganic Chemistry, 2024, 144, 107176.
Authors:  Nao, Sang Cuo;  Huang, Le Sheng;  Shiu-Hin Chan, Daniel;  Wang, Xueliang;  Li, Guo Dong; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.5/4.7 | Submit date：2024/04/02
Drug Repurposing  Drug Screening  Iridium(Iii) Complex  Time-resolved Emission  Uracil-dna Glycosylase  
Antidepressants as Autophagy Modulators for Cancer Therapy Review article
2023
Authors:  He, Leping;  Fu, Yuanfeng;  Tian, Yuxi;  Wang, Xiaofeng;  Zhou, Xuejun; et al.
Favorite | TC[WOS]:5 TC[Scopus]:6  IF:4.2/4.6 | Submit date：2024/01/10
Antidepressants  Autophagy  Cancer Therapy  Drug Repurposing  Molecular Mechanism  
Repurposing the Hedgehog pathway inhibitor, BMS-833923, as a phosphatidylglycerol-selective membrane-disruptive colistin adjuvant against ESKAPE pathogens Journal article
Zhang,Nian, Shan,Wenying, Gao,Liangliang, Kou,Si Hoi, Lu,Chang, Yang,Huilin, Peng,Bo, Tam,Kin Yip, Lee,Leo Tsz On, Zheng,Jun. Repurposing the Hedgehog pathway inhibitor, BMS-833923, as a phosphatidylglycerol-selective membrane-disruptive colistin adjuvant against ESKAPE pathogens[J]. International Journal of Antimicrobial Agents, 2023, 62(3), 106888.
Authors:  Zhang,Nian;  Shan,Wenying;  Gao,Liangliang;  Kou,Si Hoi;  Lu,Chang; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:4.9/5.6 | Submit date：2023/08/03
Antibiotic Resistance  Colistin Adjuvant  Drug Repurposing  Eskape  Membrane-disruptive Drug  
Self-Degradable Nanogels Reshape Immunosuppressive Tumor Microenvironment via Drug Repurposing Strategy to Reactivate Cytotoxic CD8+ T Cells Journal article
Tian,Hao, Li,Wenxi, Wang,Guohao, Tian,Ye, Yan,Jie, Zhou,Songtao, Yu,Xinying, Li,Bei, Dai,Yunlu. Self-Degradable Nanogels Reshape Immunosuppressive Tumor Microenvironment via Drug Repurposing Strategy to Reactivate Cytotoxic CD8+ T Cells[J]. Advanced Science, 2023, 10(21).
Authors:  Tian,Hao;  Li,Wenxi;  Wang,Guohao;  Tian,Ye;  Yan,Jie; et al.
Favorite | TC[WOS]:6 TC[Scopus]:11  IF:14.3/16.3 | Submit date：2023/08/03
Cd8++++ t Cells  Drug Repurposing  Immunosuppressive Tumor Microenvironment  Self-degradable Nanogels  
Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study Journal article
Ribaudo, Giovanni, Yun, Xiaoyun, Ongaro, Alberto, Oselladore, Erika, Ng, Jerome P L., Haynes, Richard K., Law, Betty Yuen Kwan, Memo, Maurizio, Wong, Vincent Kam Wai, Coghi, Paolo, Gianoncelli, Alessandra. Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study[J]. Chemical Biology and Drug Design, 2022.
Authors:  Ribaudo, Giovanni;  Yun, Xiaoyun;  Ongaro, Alberto;  Oselladore, Erika;  Ng, Jerome P L.; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:3.2/2.9 | Submit date：2023/01/30
Antimalarial Drugs  Drug Repurposing  Papain-like Protease  Pl-pro  Sars-cov-2  
Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity Journal article
Yuan, Si Yu, Yu, Hai Bo, Yang, Zhen, Qin, Yi Ping, Ren, Ji Hua, Cheng, Sheng Tao, Ren, Fang, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai, Ng, Jerome P.L., Zhou, Yu Jiao, He, Xin, Tan, Ming, Zhang, Zhen Zhen, Chen, Juan. Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity[J]. Frontiers in Pharmacology, 2022, 13.
Authors:  Yuan, Si Yu;  Yu, Hai Bo;  Yang, Zhen;  Qin, Yi Ping;  Ren, Ji Hua; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:4.4/5.0 | Submit date：2023/01/30
Anti-hbv Agents  Drug Repurposing  Hbsag  Hepatitis b Virus  Pimobendan  
Long COVID and its Management Review article
2022
Authors:  Koc, Ho Cheng;  Xiao, Jing;  Liu, Weiwei;  Li, Yong;  Chen, Guokai
Favorite | TC[WOS]:111 TC[Scopus]:123  IF:8.2/8.3 | Submit date：2022/08/05
Covid-19  Drug Repurposing  Long Covid  Management  Post-acute Covid Syndrome (Pacs)  Post-acute Sequelae Of Sars-cov-2 (Pasc)  Risk Factor  Sars  Sars-cov-2  Vaccine  
Screening of chemical libraries for new antifungal drugs against aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine Journal article
Dos Reis, Thaila Fernanda, Horta, Maria Augusta Crivelente, Colabardini, Ana Cristina, Fernandes, Caroline Mota, Silva, Lilian Pereira, Bastos, Rafael Wesley, Fonseca, Maria Vitória de Lazari, Wang, Fang, Martins, Celso, Rodrigues, Márcio L., Pereira, Cristina Silva, Del Poeta, Maurizio, Wong, Koon Ho, Goldman, Gustavo H.. Screening of chemical libraries for new antifungal drugs against aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine[J]. mBio, 2021, 12(4), e01458-21.
Authors:  Dos Reis, Thaila Fernanda;  Horta, Maria Augusta Crivelente;  Colabardini, Ana Cristina;  Fernandes, Caroline Mota;  Silva, Lilian Pereira; et al.
Favorite | TC[WOS]:8 TC[Scopus]:10  IF:5.1/5.9 | Submit date：2022/05/13
Aspergillus Fumigatus  Drug Repurposing  Miltefosine  Sphingolipids  Transcription Factor