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Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability Journal article
Benjamin Tam, Philip Naderev P. Lagniton, Mariano da Luz, Bojin Zhao, Siddharth Sinha, Chon Lok Lei, San Ming Wang. Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability[J]. Briefings in Bioinformatics, 2024, 25(5), bbae400.
Authors:  Benjamin Tam;  Philip Naderev P. Lagniton;  Mariano da Luz;  Bojin Zhao;  Siddharth Sinha; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.8/7.9 | Submit date：2024/08/07
Ramachandran Plot  Molecular Dynamics Simulations  Tp53  Somatic Missense Variants  
Pathogenic variants in human DNA damage repair genes mostly arose after the latest human out-of-Africa migration Journal article
He, Jun, Kou, Si Hoi, Li, Jiaheng, Ding, Xiaofan, Wang, San Ming. Pathogenic variants in human DNA damage repair genes mostly arose after the latest human out-of-Africa migration[J]. Frontiers in Genetics, 2024, 15, 1408952.
Authors:  He, Jun;  Kou, Si Hoi;  Li, Jiaheng;  Ding, Xiaofan;  Wang, San Ming
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:2.8/3.3 | Submit date：2024/08/05
Brca  Ddr Genes  Evolution Origin  Pathogenic Variants  Tp53  
DARVIC: Dihedral angle-reliant variant impact classifier for functional prediction of missense VUS Journal article
Lagniton,Philip Naderev P., Tam,Benjamin, Wang,San Ming. DARVIC: Dihedral angle-reliant variant impact classifier for functional prediction of missense VUS[J]. Computer Methods and Programs in Biomedicine, 2023, 238, 107596.
Authors:  Lagniton,Philip Naderev P.;  Tam,Benjamin;  Wang,San Ming
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:4.9/5.5 | Submit date：2023/08/03
Dihedral Angles  Human Muty Homolog (Mutyh)  Missense Variants  Molecular Dynamics Simulations (Md Simulations)  Protein Structure  Ramachandran Principle  Tumor Protein 53 (Tp53)  
Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications Journal article
Guo, Libin, Tang, Xiaoqiong, Wong, Sin Wa, Guo, Anyuan, Lin, Yao, Kwok, Hang Fai. Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications[J]. Frontiers in Pharmacology, 2022, 13, 1022129.
Authors:  Guo, Libin;  Tang, Xiaoqiong;  Wong, Sin Wa;  Guo, Anyuan;  Lin, Yao; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:4.4/5.0 | Submit date：2023/01/30
Anti-pd-1  Ifn-γ  Kras  Myc  Pd-l1 Expression  Tp53  Ifn-gamma  
Comprehensive identification of deleterious TP53 missense VUS variants based on their impact on TP53 structural stability Journal article
Wang, S. M.. Comprehensive identification of deleterious TP53 missense VUS variants based on their impact on TP53 structural stability[J]. Int J Mol Sci, 2021.
Authors:  Wang, S. M.
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2022/07/27
Tp53  Vus  Deleterious  Molecular Dynamic Simulations  Ramachandran Plot  
Comprehensive identification of deleterious TP53 missense VUS variants based on their impact on TP53 structural stability Journal article
Benjamin Tam, Siddharth Sinha, Zixin Qin, San Ming Wang. Comprehensive identification of deleterious TP53 missense VUS variants based on their impact on TP53 structural stability[J]. International Journal of Molecular Sciences, 2021, 22(21), 11345.
Authors:  Benjamin Tam;  Siddharth Sinha;  Zixin Qin;  San Ming Wang
Favorite | TC[WOS]:7 TC[Scopus]:7 | Submit date：2021/12/08
Deleterious  Molecular Dynamic Simulations  Ramachandran Plot  Tp53  Vus  
Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model Journal article
Tam,Benjamin, Sinha,Siddharth, Wang,San Ming. Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model[J]. Computational and Structural Biotechnology Journal, 2020, 18, 4033-4039.
Authors:  Tam,Benjamin;  Sinha,Siddharth;  Wang,San Ming
Favorite | TC[WOS]:32 TC[Scopus]:35 | Submit date：2021/03/02
Molecular Dynamic Simulation  Pathogenic  Protein Structure  Ramachandran Plot  Tp53  Variant Of Uncertain Significance  
Combining Ramachandran Plot and Molecular Dynamics Simulation for structural-based variant classification: using TP53 variants as model Journal article
Tam,Benjamin, Sinha,Siddharth, Wang,San Ming. Combining Ramachandran Plot and Molecular Dynamics Simulation for structural-based variant classification: using TP53 variants as model[J]. Computational and Structural Biotechnology Journal, 2020, 18, 4033-4039.
Authors:  Tam,Benjamin;  Sinha,Siddharth;  Wang,San Ming
Favorite | TC[WOS]:32 TC[Scopus]:35 | Submit date：2022/07/27
Molecular Dynamic Simulation  Pathogenic  Protein Structure  Ramachandran Plot  Tp53  Variant Of Uncertain Significance