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HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling Journal article
Zhang, Yiming, Pan, Ruilin, Li, Kun, Cheang, Lek Hang, Zhao, Jing, Zhong, Zhangfeng, Li, Shaoping, Wang, Jinghao, Zhang, Xiaofang, Cheng, Yanmei, Zheng, Xiaofei, He, Rongrong, Wang, Huajun. HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling[J]. International Journal of Biological Sciences, 2024, 20(13), 5162-5190.
Authors:  Zhang, Yiming;  Pan, Ruilin;  Li, Kun;  Cheang, Lek Hang;  Zhao, Jing; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.2/8.3 | Submit date：2024/11/05
Atp5a1  Hspd1  Multiomics Analysis  Osteosarcoma  Oxidative Phosphorylation  Ubiquitination  
Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63-specific ubiquitination Journal article
Ding Moyu, Ning Chengqing, Chen Shaoru, Yin Haoran, Xu Jing, WANG YING. Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63-specific ubiquitination[J]. doi: 10.1111/bph.17320, 2024, 181(22), 1–18.
Authors:  Ding Moyu;  Ning Chengqing;  Chen Shaoru;  Yin Haoran;  Xu Jing; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:6.8/7.4 | Submit date：2024/10/06
Immunosuppressive Activity  Inflammasome-driven Disease  K63-linked Ubiquitination,  Nlrp3  Triptolide Derivative  Triptolidiol  
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1 Journal article
Duan, Chunyan, Li, Yue, Zhi, Haoyu, Tian, Yao, Huang, Zhengyun, Chen, Suping, Zhang, Yang, Liu, Qing, Zhou, Liang, Jiang, Xiaogang, Ullah, Kifayat, Guo, Qing, Liu, Zhaohui, Xu, Ying, Han, Junhai, Hou, Jiajie, O’Connor, Darran P., Xu, Guo qiang. E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1[J]. ACTA PHARMACOLOGICA SINICA, 2024, 45, 1793-1808.
Authors:  Duan, Chunyan;  Li, Yue;  Zhi, Haoyu;  Tian, Yao;  Huang, Zhengyun; et al.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:6.9/7.6 | Submit date：2024/06/05
Bmal1  Circadian Rhythm  Proteomics  Transcriptional Activity  Ubiquitination  Ubr5  
Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase Journal article
Guan, Xiaoqing, Wang, Yichao, Yu, Wenkai, Wei, Yong, Lu, Yang, Dai, Enyu, Dong, Xiaowu, Zhao, Bing, Hu, Can, Yuan, Li, Luan, Xin, Miao, Kai, Chen, Bonan, Cheng, Xiang Dong, Zhang, Weidong, Qin, Jiang Jiang. Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase[J]. Advanced Science, 2024, 11(18), 2307899.
Authors:  Guan, Xiaoqing;  Wang, Yichao;  Yu, Wenkai;  Wei, Yong;  Lu, Yang; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:14.3/16.3 | Submit date：2024/05/16
Ferroptosis  Gastric Cancer  Scd  Ubiquitination  Usp7  Usp7 Inhibitor  
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy Journal article
Linghu, Ke-Gang, Zhang, Tian, Zhang, Guang-Tao, Lv, Peng, Zhang, Wenjun, Zhao, Guanding, Xiong, Shihong, Zhao, Mingming, Chen, Meiwan, HU YUANJIA, Zhang, Changsheng, Yu, Hua. Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(3), 401-415.
Authors:  Linghu, Ke-Gang;  Zhang, Tian;  Zhang, Guang-Tao;  Lv, Peng;  Zhang, Wenjun; et al.
Favorite | TC[WOS]:6 TC[Scopus]:9  IF:6.1/6.8 | Submit date：2024/01/02
Deoxynyboquinone  Anti-inflammation  Target  Keap1/nrf2  Alkylation  Ubiquitination  
FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation Journal article
He, Tianyu, Wang, Yanye, Lv, Wang, Wang, Yiqing, Li, Xinye, Zhang, Qingyi, Shen, Han Ming, Hu, Jian. FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation[J]. Cellular and Molecular Life Sciences, 2024, 81(1), 87.
Authors:  He, Tianyu;  Wang, Yanye;  Lv, Wang;  Wang, Yiqing;  Li, Xinye; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:6.2/7.7 | Submit date：2024/05/16
Fbp1  Nicd1  Nsclc  Stemness  Ubiquitination  
GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer Journal article
Jiang, Qiwei, Li, Yong, Cai, Songwang, Shi, Xingyuan, Yang, Yang, Xing, Zihao, He, Zhenjie, Wang, Shengte, Su, Yubin, Chen, Meiwan, Chen, Zhesheng, Shi, Zhi. GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer[J]. Acta Pharmaceutica Sinica B, 2023, 14(2), 698-711.
Authors:  Jiang, Qiwei;  Li, Yong;  Cai, Songwang;  Shi, Xingyuan;  Yang, Yang; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:14.7/14.1 | Submit date：2024/02/22
Enzyme  Gastric Cancer  Glul  N-cadherin  Protein Stability  Protein-protein Interaction  Ubiquitination  Β-catenin  
USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression Journal article
Liu Xiaojia, Lu Runhui, Yang Qianqian, XIE Ruiyu, Zhao Xian, YU Xianxiu. USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression[J]. Molecular Oncology, 2023, 18(1), 170-189.
Authors:  Liu Xiaojia;  Lu Runhui;  Yang Qianqian;  XIE Ruiyu;  Zhao Xian; et al.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:5.0/6.5 | Submit date：2023/12/29
Cancer Progression  Dicer  Mdm2  Ubiquitination  Usp7  
The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy Journal article
Shan Sun, Hongyu Hou, Guoqiang Ma, Qilian Ma, Ningning Li, Li Zhang, Chunsheng Dong, Mian Cao, Kin Yip Tam, Zheng Ying, Hongfeng Wang. The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 298(12), 102704.
Authors:  Shan Sun;  Hongyu Hou;  Guoqiang Ma;  Qilian Ma;  Ningning Li; et al.
Favorite | TC[WOS]:18 TC[Scopus]:18  IF:4.0/4.4 | Submit date：2023/01/30
Mitophagy  Parkin  Phb2  Ubiquitination  Map1lc3b/lc3b  
Post-translational Modification in Control of SIRT1 Stability during DNA Damage Response Journal article
Ouyang, Chenxi, Lu, Guang, He, Weifeng, Bay, Boon Huat, Shen, Han Ming. Post-translational Modification in Control of SIRT1 Stability during DNA Damage Response[J]. International Journal of Biological Sciences, 2022, 18(7), 2655-2669.
Authors:  Ouyang, Chenxi;  Lu, Guang;  He, Weifeng;  Bay, Boon Huat;  Shen, Han Ming
Favorite | TC[WOS]:8 TC[Scopus]:7  IF:8.2/8.3 | Submit date：2022/07/20
Caspases  Cleavage  Ddr  Sirt1  Trim28  Ubiquitination