An event-triggered integral sliding mode control (ETISMC) approach for the networked nonlinear active suspension systems (ASSs) via interval type-2 (IT-2) T-S fuzzy logic is investigated in this paper. Firstly, in order to deal with the uncertainty in system masses, the nonlinearity of the suspension spring stiffness and damping coefficient, and the unknown actuator nonlinearity simultaneously, an ASSs model based on the IT-2 T-S fuzzy method is constructed. Secondly, a discrete event-triggered method is designed to process the sampled data and reduce the usage of vehicle CAN network communication resources. Thirdly, the H infinity robust method is used to handle the road disturbance and the sliding mode control (SMC) is adopted to deal with the actuator input uncertainty. To better integrate the SMC and event-triggered control (ETC), an ETISMC approach is explored for the ASSs. Finally, the numerical simulations and experiments are conducted to validate the effectiveness of the proposed strategy in this work.