Barrier-free facility is very important for handicapped daily life. Nevertheless, a good wheelchair design is helpfully supporting them. Unfortunately, sitting posture made handicapped perplexing, because the pressure ulcer problem occurs in their lower portion of body by traditional wheelchair. Since the major of the elders and the mobility patients are lower portion of body muscle or joint problems generated the travel inconvenience, therefore, it is necessary to design and study an innovative wheelchair that can aid the elders with mobility disability daily travelling a convenient transportation with multifunctional, easy-control method and superior user experience contributing to their lives. This investigation is going to discuss the possibility and feasibility of the smart wheelchair by Human Factors Engineering Technology to provide a comfortable and safety circumstance to the users, which can reduce the pressure ulcer problem by changing sitting posture with muscle signal control (EMG) and brain wave control (EEG).