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The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk Journal article
Lei, Chon Lok, Whittaker, Dominic G., Mirams, Gary R.. The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk[J]. British Journal of Pharmacology, 2024, 181(7), 987-1004.
Authors:  Lei, Chon Lok;  Whittaker, Dominic G.;  Mirams, Gary R.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:6.8/7.4 | Submit date：2024/02/22
Binding Mechanism  Cipa  Herg  Mathematical Modelling  Proarrhythmic Risk  Safety Pharmacology  Torsade  
From mundane to classic: Sinomenine as a multi-therapeutic agent Journal article
Li, Dan, Zhong, Zhangfeng, Ko, Chung Nga, Tian, Tiantian, Yang, Chao. From mundane to classic: Sinomenine as a multi-therapeutic agent[J]. British Journal of Pharmacology, 2023.
Authors:  Li, Dan;  Zhong, Zhangfeng;  Ko, Chung Nga;  Tian, Tiantian;  Yang, Chao
Favorite | TC[WOS]:8 TC[Scopus]:10  IF:6.8/7.4 | Submit date：2024/02/22
Anti-inflammatory  Anticancer  Depression  Neuroprotection  Oxidative Stress  Sinomenine  Traditional Chinese Medicine  
Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63-specific ubiquitination Journal article
Ding Moyu, Ning Chengqing, Chen Shaoru, Yin Haoran, Xu jing, WANG YING. Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63-specific ubiquitination[J]. British Journal of Pharmacology, 2023.
Authors:  Ding Moyu;  Ning Chengqing;  Chen Shaoru;  Yin Haoran;  Xu jing; et al.
Favorite |   IF:6.8/7.4 | Submit date：2024/08/24
Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways Journal article
Liu, Yi, Li, Han, Luo, Zhihong, Yu, You, Yang, Jingzhao, Zhang, Min, Law, Betty Yuen Kwan, Huang, Zan, Li, Wenhua. Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways[J]. British Journal of Pharmacology, 2022, 180(6), 701-720.
Authors:  Liu, Yi;  Li, Han;  Luo, Zhihong;  Yu, You;  Yang, Jingzhao; et al.
Favorite | TC[WOS]:4 TC[Scopus]:4  IF:6.8/7.4 | Submit date：2023/01/30
Acute Myeloid Leukaemia  Apoptosis  Artesunate  Bim  Differentiation  Tfrc  
Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate Journal article
Feng, Zheling, Chen, Jiali, Chen, Cheng, Feng, Lu, Wang, Rui, Zhu, Jianzhong, Lou, Ruohan, Liu, Jia, Ye, Yang, Lin, Ligen. Bioactivity-based molecular networking-guided identification of guttiferone J from Garcinia cambogia as an anti-obesity candidate[J]. British Journal of Pharmacology, 2022, 180(5), 589-608.
Authors:  Feng, Zheling;  Chen, Jiali;  Chen, Cheng;  Feng, Lu;  Wang, Rui; et al.
Favorite | TC[WOS]:9 TC[Scopus]:10  IF:6.8/7.4 | Submit date：2023/04/03
Anti-obesity  Bioactivity-based Molecular Networking  Garcinia Cambogia  Guttiferone j  Sirtuin 3  White Adipose Tissue Browning  
Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk Journal article
Yangyang Zhou, Caifang Gao, Chi Teng Vong, Hongxun Tao, Hongyi Li, Shengpeng Wang, Yitao Wang. Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2021, 179(9), 1978-1997.
Authors:  Yangyang Zhou;  Caifang Gao;  Chi Teng Vong;  Hongxun Tao;  Hongyi Li; et al.
Favorite | TC[WOS]:44 TC[Scopus]:48  IF:6.8/7.4 | Submit date：2022/05/13
Anthraquinone  Colonic Inflammation  Macrophage Polarization  Nadph Oxidase  Nlrp3 Inflammasome  Nrf2  
Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis Journal article
Wang,Zi Xuan, Ma,Jing, Li,Xin Yu, Wu,Yong, Shi,Huan, Chen,Yao, Lu,Guang, Shen,Han Ming, Lu,Guo Dong, Zhou,Jing. Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2021, 178(5), 1133-1148.
Authors:  Wang,Zi Xuan;  Ma,Jing;  Li,Xin Yu;  Wu,Yong;  Shi,Huan; et al.
Favorite | TC[WOS]:136 TC[Scopus]:135  IF:6.8/7.4 | Submit date：2021/03/02
Ferroptosis  Lysosome  Quercetin  Ros  Transcription Factor Eb  
Small molecule-driven SIRT3-autophagy-mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes Journal article
Zhang,Tian, Fang,Zhujun, Linghu,Ke Gang, Liu,Jingxin, Gan,Lishe, Lin,Ligen. Small molecule-driven SIRT3-autophagy-mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2020, 177(20), 4645-4665.
Authors:  Zhang,Tian;  Fang,Zhujun;  Linghu,Ke Gang;  Liu,Jingxin;  Gan,Lishe; et al.
Favorite | TC[WOS]:55 TC[Scopus]:54  IF:6.8/7.4 | Submit date：2021/03/01
Adipocytes  Adipose Tissue Inflammation  Autophagy  Cycloartane Triterpenoid  Il-1β  Macrophages  Nlrp3 Inflammasome  
Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance Journal article
Shen, SN, Liao, QW, Zhang, T, Pan, RL, Lin, LG. Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2019, 176(20), 3983-4001.
Authors:  Shen, SN;  Liao, QW;  Zhang, T;  Pan, RL;  Lin, LG
Favorite | TC[WOS]:59 TC[Scopus]:58  IF:6.8/7.4 | Submit date：2020/03/20
Myricanol modulates skeletal muscle–adipose tissue crosstalk to alleviate high‐fat diet‐induced obesity and insulin resistance Journal article
Shen, S., Liao, Q., Zhang, T., Pan, R., Lin, L.. Myricanol modulates skeletal muscle–adipose tissue crosstalk to alleviate high‐fat diet‐induced obesity and insulin resistance[J]. British Journal of Pharmacology, 2019, 3983-4001.
Authors:  Shen, S.;  Liao, Q.;  Zhang, T.;  Pan, R.;  Lin, L.
Favorite | TC[WOS]:59 TC[Scopus]:58 | Submit date：2022/07/27
Myricanol  Myotubes  Irisin  Mitochondira  Browning