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Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants Journal article
Li, Linjie, Shi, Kaiyuan, Gu, Yuhang, Xu, Zepeng, Shu, Chang, Li, Dedong, Sun, Junqing, Cong, Mengqing, Li, Xiaomei, Zhao, Xin, Yu, Guanghui, Hu, Songnian, Tan, Hui, Qi, Jianxun, Ma, Xiaopeng, Liu, Kefang, Gao, George F.. Spike structures, receptor binding, and immune escape of recently circulating SARS-CoV-2 Omicron BA.2.86, JN.1, EG.5, EG.5.1, and HV.1 sub-variants[J]. Structure, 2024, 32(8), 1055-1067.e6.
Authors:  Li, Linjie;  Shi, Kaiyuan;  Gu, Yuhang;  Xu, Zepeng;  Shu, Chang; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:4.4/4.3 | Submit date：2024/08/05
Ba.2.86  Eg.5  Eg.5.1  Hace2  Hv.1  Jn.1  Rbd  Sars-cov-2  
Neutralization of EG.5, EG.5.1, BA.2.86, and JN.1 by antisera from dimeric receptor-binding domain subunit vaccines and 41 human monoclonal antibodies Journal article
He, Qingwen, An, Yaling, Zhou, Xuemei, Xie, Haitang, Tao, Lifeng, Li, Dedong, Zheng, Anqi, Li, Linjie, Xu, Zepeng, Yu, Shufan, Wang, Ruyue, Hu, Hua, Liu, Kefang, Wang, Qihui, Dai, Lianpan, Xu, Kun, Gao, George F.. Neutralization of EG.5, EG.5.1, BA.2.86, and JN.1 by antisera from dimeric receptor-binding domain subunit vaccines and 41 human monoclonal antibodies[J]. Med, 2024, 5(5), 401-413.e4.
Authors:  He, Qingwen;  An, Yaling;  Zhou, Xuemei;  Xie, Haitang;  Tao, Lifeng; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3 | Submit date：2024/05/16
Ba.2.86  Eg.5  Eg.5.1  Immune Evasion  Jn.1  Neutralizing Antibody  Rbd-dimer  Sars-cov-2  Translation To Humans  Zf2001 Vaccine  Zf2202-a  
Key mechanistic features of the trade-off between antibody escape and host cell binding in the SARS-CoV-2 Omicron variant spike proteins Journal article
Li, Weiwei, Xu, Zepeng, Niu, Tianhui, Xie, Yufeng, Zhao, Zhennan, Li, Dedong, He, Qingwen, Sun, Wenqiao, Shi, Kaiyuan, Guo, Wenjing, Chang, Zhen, Liu, Kefang, Fan, Zheng, Qi, Jianxun, Gao, George F.. Key mechanistic features of the trade-off between antibody escape and host cell binding in the SARS-CoV-2 Omicron variant spike proteins[J]. EMBO Journal, 2024, 43(8), 1484-1498.
Authors:  Li, Weiwei;  Xu, Zepeng;  Niu, Tianhui;  Xie, Yufeng;  Zhao, Zhennan; et al.
Favorite | TC[WOS]:7 TC[Scopus]:6  IF:9.4/11.0 | Submit date：2024/05/02
Immune Evasion  Omicron  Receptor Binding  Sars-cov-2  Sub-variants  
Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency Journal article
Shi, Kaiyuan, Li, Linjie, Luo, Chunliang, Xu, Zepeng, Huang, Baihan, Ma, Sufang, Liu, Kefang, Yu, Guanghui, Gao, George F.. Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency[J]. mBio, 2024, 15(2), e02988-23.
Authors:  Shi, Kaiyuan;  Li, Linjie;  Luo, Chunliang;  Xu, Zepeng;  Huang, Baihan; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:5.1/5.9 | Submit date：2024/03/07
Ace2  Cryo-em Structure  Hare  Rabbit  Rbd  Sars-cov  Sars-cov-2  Spike (s) Proteins  
The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses Journal article
Chen, Junsen, Sun, Junqing, Xu, Zepeng, Li, Linjie, Kang, Xinrui, Luo, Chunliang, Wang, Qi, Guo, Xueyang, Li, Yan, Liu, Kefang, Wu, Ying. The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses[J]. Virologica Sinica, 2024, 39(4), 609-618.
Authors:  Chen, Junsen;  Sun, Junqing;  Xu, Zepeng;  Li, Linjie;  Kang, Xinrui; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:4.3/4.3 | Submit date：2024/08/05
Cryo-em Structure  Fox Ace2  Omicron  Sarbecoviruses  Sars-cov  Sars-cov-2  
Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2 Journal article
Rao, Xia, Zhao, Runchu, Tong, Zhou, Guo, Shuxin, Peng, Weiyu, Liu, Kefang, Li, Shihua, Wu, Lili, Tong, Jianyu, Chai, Yan, Han, Pu, Wang, Feiran, Jia, Peng, Li, Zhaohui, Zhao, Xin, Li, Dedong, Zhang, Rong, Zhang, Xue, Zou, Weiwei, Li, Weiwei, Wang, Qihui, Gao, George Fu, Wu, Yan, Dai, Lianpan, Gao, Feng. Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2[J]. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120(52), e2314193120.
Authors:  Rao, Xia;  Zhao, Runchu;  Tong, Zhou;  Guo, Shuxin;  Peng, Weiyu; et al.
Favorite | TC[WOS]:8 TC[Scopus]:9  IF:9.4/10.8 | Submit date：2024/01/02
Cryptic Epitope  Neutralizing Antibody  Omicron Ba.4/ba.5/bq.1.1/xbb Subvariant  Rbd-8  Sars-cov-2  
Structural basis of white-tailed deer, Odocoileus virginianus, ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity Journal article
Han, Pu, Meng, Yumin, Zhang, Di, Xu, Zepeng, Li, Zhiyuan, Pan, Xiaoqian, Zhao, Zhennan, Li, Linjie, Tang, Lingfeng, Qi, Jianxun, Liu, Kefang, Gao, George F.. Structural basis of white-tailed deer, Odocoileus virginianus, ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity[J]. Journal of Virology, 2023, 97(9), e00505.
Authors:  Han, Pu;  Meng, Yumin;  Zhang, Di;  Xu, Zepeng;  Li, Zhiyuan; et al.
Favorite | TC[WOS]:5 TC[Scopus]:6  IF:4.0/4.0 | Submit date：2024/01/10
Ace2  Cryo-em Structure  Odocoileus Virginianus  Rbd  s Proteins  Sars-cov-2  White-tailed Deer  
Broad protective RBD heterotrimer vaccines neutralize SARS-CoV-2 including Omicron sub-variants XBB/BQ.1.1/BF.7 Journal article
Yanfang Zhang, Xinrui Kang, Sheng Liu, Pu Han, Wenwen Lei, Ke Xu, Zepeng Xu, Zhengrong Gao, Xuemei Zhou, Yaling An, Yuxuan Han, Kefang Liu, Xin Zhao, Lianpan Dai, Peiyi Wang, Guizhen Wu, Jianxun Qi, Kun Xu, George F. Gao. Broad protective RBD heterotrimer vaccines neutralize SARS-CoV-2 including Omicron sub-variants XBB/BQ.1.1/BF.7[J]. PLoS Pathogens, 2023, 19(9), e1011659.
Authors:  Yanfang Zhang;  Xinrui Kang;  Sheng Liu;  Pu Han;  Wenwen Lei; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:5.5/5.5 | Submit date：2023/10/10
Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants Journal article
Zhao,Zhennan, Xie,Yufeng, Bai,Bin, Luo,Chunliang, Zhou,Jingya, Li,Weiwei, Meng,Yumin, Li,Linjie, Li,Dedong, Li,Xiaomei, Li,Xiaoxiong, Wang,Xiaoyun, Sun,Junqing, Xu,Zepeng, Sun,Yeping, Zhang,Wei, Fan,Zheng, Zhao,Xin, Wu,Linhuan, Ma,Juncai, Li,Odel Y., Shang,Guijun, Chai,Yan, Liu,Kefang, Wang,Peiyi, Gao,George F., Qi,Jianxun. Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants[J]. Nature Communications, 2023, 14(1), 4405.
Authors:  Zhao,Zhennan;  Xie,Yufeng;  Bai,Bin;  Luo,Chunliang;  Zhou,Jingya; et al.
Favorite | TC[WOS]:15 TC[Scopus]:16  IF:14.7/16.1 | Submit date：2023/08/03
Host range and structural analysis of bat-origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs Journal article
Hu, Yu, Liu, Kefang, Han, Pu, Xu, Zepeng, Zheng, Anqi, Pan, Xiaoqian, Jia, Yunfei, Su, Chao, Tang, Lingfeng, Wu, Lili, Bai, Bin, Zhao, Xin, Tian, Di, Chen, Zhihai, Qi, Jianxun, Wang, Qihui, Gao, George F.. Host range and structural analysis of bat-origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs[J]. EMBO Journal, 2023, 42(4).
Authors:  Hu, Yu;  Liu, Kefang;  Han, Pu;  Xu, Zepeng;  Zheng, Anqi; et al.
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:9.4/11.0 | Submit date：2023/03/06
Ace2  Interspecies Transmission  Rbd  Rshstt182/200  Sars-cov-2