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BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1 Journal article
Ren, Guowen, Chen, Jinghong, Pu, Yue, Yang, Eun Ju, Tao, Shishi, Mou, Pui Kei, Chen, Li Jie, Zhu, Wenli, Chan, Kin Long, Luo, Guanghui, Deng, Chuxia, Shim, Joong Sup. BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21CIP1/WAF1[J]. International Journal of Biological Sciences, 2024, 20(6), 1978-1991.
Authors:  Ren, Guowen;  Chen, Jinghong;  Pu, Yue;  Yang, Eun Ju;  Tao, Shishi; et al.
Favorite | TC[WOS]:1 TC[Scopus]:1  IF:8.2/8.3 | Submit date：2024/05/16
Akt  Bet  Colorectal Cancer  Myc  P21  PhosphorylAted P21 At Thr145  Pten  Synthetic Lethality  
ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones Journal article
Shishi Tao, Eun Ju Yang, Guanghui Zong, Pui Kei Mou, Guowen Ren, Yue Pu, Liang Chen, Ho Jeong Kwon, Jianhong Zhou, Zhijian Hu, Arman Khosravi, Qingyang Zhang, Yuchun Du, Wei Q. Shi, Joong Sup Shim. ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones[J]. Int J Biol Sci, 2023, 19(13), 4020-4035.
Authors:  Shishi Tao;  Eun Ju Yang;  Guanghui Zong;  Pui Kei Mou;  Guowen Ren; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:8.2/8.3 | Submit date：2023/08/30
Ipomoeassin f  Er Stress  Er Translocon  Tnbc  Pdia6  Pdia4  
MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism Journal article
Guowen Ren, Eun Ju Yang, Shishi Tao, Pui Kei Mou, Yue Pu, Li-Jie Chen, Joong Sup Shim. MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism[J]. Int J Biol Sci, 2023, 19(11), 3544-3557.
Authors:  Guowen Ren;  Eun Ju Yang;  Shishi Tao;  Pui Kei Mou;  Yue Pu; et al.
Favorite |   IF:8.2/8.3 | Submit date：2023/08/30
Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation Journal article
Changxiang Shi, Shishi Tao, Guowen Ren, Eun Ju Yang, Xiaodong Shu, Pui Kei Mou, Yifan Liu, Yongjun Dang, Xiaoling Xu, Joong Sup Shim. Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation[J]. Oncogene, 2022, 41(19), 2734-2748.
Authors:  Changxiang Shi;  Shishi Tao;  Guowen Ren;  Eun Ju Yang;  Xiaodong Shu; et al.
Favorite | TC[WOS]:6 TC[Scopus]:6  IF:6.9/7.5 | Submit date：2022/05/31
Natural products targeting cancer cell dependency Review article
2021
Authors:  Changxiang Shi;  Eun Ju Yang;  Shishi Tao;  Guowen Ren;  Pui Kei Mou; et al.
Favorite | TC[WOS]:8 TC[Scopus]:9  IF:2.1/2.5 | Submit date：2021/12/08
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics Journal article
Ding, Ren Bo, Chen, Ping, Rajendran, Barani Kumar, Lyu, Xueying, Wang, Haitao, Bao, Jiaolin, Zeng, Jianming, Hao, Wenhui, Sun, Heng, Wong, Ada Hang Heng, Valecha, Monica Vishnu, Yang, Eun Ju, Su, Sek Man, Choi, Tak Kan, Liu, Shuiming, Chan, Kin Iong, Yang, Ling Lin, Wu, Jingbo, Miao, Kai, Chen, Qiang, Shim, Joong Sup, Xu, Xiaoling, Deng, Chu Xia. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics[J]. Nature Communications, 2021, 12(1), 3046.
Authors:  Ding, Ren Bo;  Chen, Ping;  Rajendran, Barani Kumar;  Lyu, Xueying;  Wang, Haitao; et al.
Favorite | TC[WOS]:53 TC[Scopus]:51  IF:14.7/16.1 | Submit date：2021/11/30
Aurora kinase A, a synthetic lethal target for precision cancer medicine Review article
2021
Authors:  Mou, Pui Kei;  Yang, Eun Ju;  Shi, Changxiang;  Ren, Guowen;  Tao, Shishi; et al.
Favorite | TC[WOS]:63 TC[Scopus]:63  IF:9.5/11.7 | Submit date：2021/12/07
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Shi,Changxiang, Yang,Eun Ju, Liu,Yifan, Mou,Pui Kei, Ren,Guowen, Shim,Joong Sup. Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression[J]. Oncogene, 2021, 40(5), 937-950.
Authors:  Shi,Changxiang;  Yang,Eun Ju;  Liu,Yifan;  Mou,Pui Kei;  Ren,Guowen; et al.
Favorite | TC[WOS]:14 TC[Scopus]:14  IF:6.9/7.5 | Submit date：2021/03/04
Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Lyu,Junfang, Yang,Eun Ju, Zhang,Baoyuan, Wu,Changjie, Pardeshi,Lakhansing, Shi,Changxiang, Mou,Pui Kei, Liu,Yifan, Tan,Kaeling, Shim,Joong Sup. Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics[J]. Nature Communications, 2020, 11(1), 5105.
Authors:  Lyu,Junfang;  Yang,Eun Ju;  Zhang,Baoyuan;  Wu,Changjie;  Pardeshi,Lakhansing; et al.
Favorite | TC[WOS]:37 TC[Scopus]:36  IF:14.7/16.1 | Submit date：2021/03/04
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Zhang,Baoyuan, Lyu,Junfang, Yang,Eun Ju, Liu,Yifan, Wu,Changjie, Pardeshi,Lakhansing, Tan,Kaeling, Chen,Qiang, Xu,Xiaoling, Deng,Chu Xia, Shim,Joong Sup. Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells[J]. Acta Pharmaceutica Sinica B, 2020, 10(4), 615-627.
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie; et al.
Favorite | TC[WOS]:23 TC[Scopus]:28  IF:14.7/14.1 | Submit date：2020/09/16
Brca1  Histone Deacetylase  Hdac  Synthetic Lethality  Reactive Oxygen Species  Dna Damage  Breast Cancer