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Development of a sensitive luminescent probe to uncover new BRD4 inhibitors in living cells Journal article
Song, Ying Qi, Wu, Ke Jia, Zhang, Zhiming, Liu, Tzu-Ming, Ko, Chung Nga, Zhu, Wei Guo, Ma, Dik Lung, Wang, Wanhe, Leung, Chung Hang. Development of a sensitive luminescent probe to uncover new BRD4 inhibitors in living cells[J]. Chemical Engineering Journal, 2023, 463, 142356.
Authors:  Song, Ying Qi;  Wu, Ke Jia;  Zhang, Zhiming;  Liu, Tzu-Ming;  Ko, Chung Nga; et al.
Favorite | TC[WOS]:7 TC[Scopus]:7  IF:13.3/13.2 | Submit date：2023/06/05
Azelastine  Brd4  Drug Screening  Inhibitor  Luminescent  Probe  
FGFR2–BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model Journal article
Lei, Josh Haipeng, Zhang, Lei, Wang, Zhenyi, Peltier, Raoul, Xie, Yusheng, Chen, Ganchao, Lin, Shiqi, Miao, Kai, Deng, Chu Xia, Sun, Hongyan. FGFR2–BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model[J]. Frontiers in Immunology, 2022, 13, 861221.
Authors:  Lei, Josh Haipeng;  Zhang, Lei;  Wang, Zhenyi;  Peltier, Raoul;  Xie, Yusheng; et al.
Favorite | TC[WOS]:0 TC[Scopus]:0  IF:5.7/6.8 | Submit date：2022/05/31
Brd4  Epigenetic  Fgfr2  Immunotherapy  Posttranslational Modifications  Tnbc  
An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells Journal article
Yang, Guan Jun, Song, Ying Qi, Wang, Wanhe, Han, Quan Bin, Ma, Dik Lung, Leung, Chung Hang. An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells[J]. BIOORGANIC CHEMISTRY, 2021, 114, 105158.
Authors:  Yang, Guan Jun;  Song, Ying Qi;  Wang, Wanhe;  Han, Quan Bin;  Ma, Dik Lung; et al.
Favorite | TC[WOS]:29 TC[Scopus]:30  IF:4.5/4.7 | Submit date：2021/12/08
Acetylated Rela  Brd4  Nf-κb  Protein-protein Interaction  Tnbc  
A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy Journal article
Yang,Guan Jun, Wang,Wanhe, Lei,Pui Man, Leung,Chung Hang, Ma,Dik Lung. A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy[J]. International Journal of Biological Macromolecules, 2020, 164, 3204-3220.
Authors:  Yang,Guan Jun;  Wang,Wanhe;  Lei,Pui Man;  Leung,Chung Hang;  Ma,Dik Lung
Favorite | TC[WOS]:26 TC[Scopus]:26  IF:7.7/7.7 | Submit date：2021/03/01
Brd4  BromoDomain Domain  Cell Metastasis And Invasion  Histone Acetylation  Melanoma  Protein–protein Interaction  Virtual Screening  
Iridium (III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent Patent
专利类型: 发明专利Invention, 专利号: US9840526B1, 申请日期: 2017-07-27,
Authors:  Chung-Hang LEUNG;  Hai-Jing ZHONG;  Dik-Lung MA;  Hui-Min WANG
Favorite |  | Submit date：2022/08/31
Brd4 Inhibitor