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The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk Journal article
Lei, Chon Lok, Whittaker, Dominic G., Mirams, Gary R.. The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk[J]. British Journal of Pharmacology, 2024, 181(7), 987-1004.
Authors:  Lei, Chon Lok;  Whittaker, Dominic G.;  Mirams, Gary R.
Favorite | TC[WOS]:3 TC[Scopus]:2  IF:6.8/7.4 | Submit date：2024/02/22
Binding Mechanism  Cipa  Herg  Mathematical Modelling  Proarrhythmic Risk  Safety Pharmacology  Torsade  
Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment Journal article
Farm,Hui Jia, Clerx,Michael, Cooper,Fergus, Polonchuk,Liudmila, Wang,Ken, Gavaghan,David J., Lei,Chon Lok. Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment[J]. Frontiers in Pharmacology, 2023, 14, 1110555.
Authors:  Farm,Hui Jia;  Clerx,Michael;  Cooper,Fergus;  Polonchuk,Liudmila;  Wang,Ken; et al.
Favorite | TC[WOS]:3 TC[Scopus]:3  IF:4.4/5.0 | Submit date：2023/08/03
Drug Binding  Drug Trapping  Ic50 (50% Inhibition Concentration)  Mathematical Modelling  Herg Channel  Action Potential Predictions