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Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells Journal article
Miao, Lingchao, Zhang, Haolin, Cheong, Meng Sam, Zhong Ruting, Garcia-Oliveira, Paula, Prieto, Miguel A, Cheng, Ka-Wing, Wang, Mingfu, Cao, Hui, Nie, Shaoping, Simal-Gandara, Jesus, Cheang, Wai San, Xiao, Jianbo. Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells[J]. Food Science and Human Wellness, 2023, 12(6), 1991-2000.
Authors:  Miao, Lingchao;  Zhang, Haolin;  Cheong, Meng Sam;  Zhong Ruting;  Garcia-Oliveira, Paula; et al.
Favorite | TC[WOS]:23 TC[Scopus]:21  IF:5.6/6.8 | Submit date：2022/08/11
Apigenin  Luteolin  Baicalein  Insulin-resistant Hepg2 Cells  Signaling Pathway  Reactive Oxygen Species (Ros)  Advanced Glycation End-products (Ages)  Glycogen Synthase Kinase (Gsk-3β)  Glucose Transporter Protein 4 (Glut4)  
Protein Kinase C Modulation Determines the Mesoderm/ Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells Journal article
Godoy-Parejo, Carlos, Deng, Chunhao, Xu, Jiaqi, Zhang, Zhaoying, Ren, Zhili, Ai, Nana, Liu, Weiwei, Ge, Wei, Deng, Chuxia, Xu, Xiaoling, Chin, Y. Eugene, Chen, Guokai. Protein Kinase C Modulation Determines the Mesoderm/ Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells[J]. Stem Cells, 2023, 41(6), 578-591.
Authors:  Godoy-Parejo, Carlos;  Deng, Chunhao;  Xu, Jiaqi;  Zhang, Zhaoying;  Ren, Zhili; et al.
Favorite | TC[WOS]:2 TC[Scopus]:1  IF:4.0/4.9 | Submit date：2023/07/19
Bmp4  Extraembryonic  Fgf  Gf109203x  Human Embryonic Stem Cells  Mesoderm  Protein Kinase c  Signaling Boundary  Trophoblast  Wnt  
Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease Journal article
Shasha Cheng, Yi Kuang, Guodong Li, Jia Wu, Chung-Nga Ko, Wanhe Wang, Dik-Lung Ma, Min Ye, Chung-Hang Leung. Dehydroeburicoic Acid, a Dual Inhibitor against Oxidative Stress in Alcoholic Liver Disease[J]. Pharmaceuticals, 2022, 16(1), 14.
Authors:  Shasha Cheng;  Yi Kuang;  Guodong Li;  Jia Wu;  Chung-Nga Ko; et al.
Favorite | TC[WOS]:2 TC[Scopus]:2  IF:4.3/4.6 | Submit date：2023/02/08
Alcoholic Liver Disease (Ald)  Glycogen Synthase Kinase 3β (Gsk3β)  Hepatoprotective  Keap1–nrf2 Protein–protein Interaction (Ppi)  
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation Journal article
Chen, Jia Yue, Zhu, Qi, Cai, Cui Zan, Luo, Hai Bin, Lu, Jia Hong. α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation[J]. Phytomedicine, 2022, 101, 154125.
Authors:  Chen, Jia Yue;  Zhu, Qi;  Cai, Cui Zan;  Luo, Hai Bin;  Lu, Jia Hong
Favorite | TC[WOS]:8 TC[Scopus]:8  IF:6.7/6.2 | Submit date：2022/05/31
Alpha-synuclein (Α-syn)  Parkinson's Disease  Phosphodiesterase 4 Inhibitor  Protein Kinase a (Pka)  Ubiquitin-proteasome System (Ups)  
Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway Journal article
Teng, Yong Jie, Deng, Zhe, Ouyang, Zhao Guang, Zhou, Qing, Mei, Si, Fan, Xing Xing, Wu, Yong Rong, Long, Hong Ping, Fang, Le Yao, Yin, Dong Liang, Zhang, Bo Yu, Guo, Yin Mei, Zhu, Wen Hao, Huang, Zhen, Zheng, Piao, Ning, Di Min, Tian, Xue Fei. Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway[J]. World Journal of Gastrointestinal Oncology, 2022, 14(4), 872-886.
Authors:  ; et al.
Favorite | TC[WOS]:5 TC[Scopus]:6  IF:2.5/2.8 | Submit date：2023/01/30
Antitumour  Apoptosis  Hepatocellular Carcinoma  Phosphoinositide 3-kinase/protein Kinase-b/mechanistic Target Of Rapamycin Pathway  Xihuang Pills  
Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer Journal article
Cheng, Sha Sha, Qu, Yuan Qing, Wu, Jia, Yang, Guan Jun, Liu, Hao, Wang, Wanhe, Huang, Qi, Chen, Feng, Li, Guodong, Wong, Chun Yuen, Wong, Vincent Kam Wai, Ma, Dik Lung, Leung, Chung Hang. Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer[J]. Acta Pharmaceutica Sinica B, 2022, 12(3), 1390-1405.
Authors:  Cheng, Sha Sha;  Qu, Yuan Qing;  Wu, Jia;  Yang, Guan Jun;  Liu, Hao; et al.
Favorite | TC[WOS]:36 TC[Scopus]:39  IF:14.7/14.1 | Submit date：2022/04/06
Epigenetics  Kinase Inhibitor  Metal Complex  Metastasis  Protein–protein Interaction  Triple-negative Breast Cancer  
S-Propargyl-cysteine prevents concanavalin A-induced immunological liver injury in mice Journal article
Ma, Beilei, Mao, Yicheng, Chang, Lingling, Dai, Tao, Xin, Xiaoming, Ma, Fenfen, Wang, Zhijun, Shen, Zhuqing, Mei, Qibing, Zhu, Yizhun. S-Propargyl-cysteine prevents concanavalin A-induced immunological liver injury in mice[J]. Pharmaceutical Biology, 2022, 60(1), 1169-1176.
Authors:  Ma, Beilei;  Mao, Yicheng;  Chang, Lingling;  Dai, Tao;  Xin, Xiaoming; et al.
Favorite | TC[WOS]:6 TC[Scopus]:6  IF:3.9/4.0 | Submit date：2023/01/30
Autoimmune Hepatitis  Cystathionine Γ-lyase  Hydrogen Sulphide  Mitogen-activated Protein Kinase  
Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells Journal article
Zhang, Yumeng, Xu, Jiaqi, Ren, Zhili, Meng, Ya, Liu, Weiwei, Lu, Ligong, Zhou, Zhou, Chen, Guokai. Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells[J]. Stem Cell Research & Therapy, 2021, 12(1), 362.
Authors:  Zhang, Yumeng;  Xu, Jiaqi;  Ren, Zhili;  Meng, Ya;  Liu, Weiwei; et al.
Favorite | TC[WOS]:12 TC[Scopus]:15  IF:7.1/7.9 | Submit date：2021/12/09
Casein Kinase 1 (Ck1)  Human Embryonic Stem Cells  Kinase Inhibitor  Nicotinamide  Pancreatic Progenitors  Rho-associated Protein Kinase (Rock)  
An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles Journal article
Ruan,Chen, Wang,Chenwei, Gong,Xuanqing, Zhang,Ying, Deng,Wankun, Zhou,Jiaqi, Huang,Dengtong, Wang,Zining, Zhang,Qiong, Guo,Anyuan, Lu,Jiahong, Gao,Jinhao, Peng,Di, Xue,Yu. An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles[J]. Autophagy, 2021, 17(6), 1426-1447.
Authors:  Ruan,Chen;  Wang,Chenwei;  Gong,Xuanqing;  Zhang,Ying;  Deng,Wankun; et al.
Favorite | TC[WOS]:35 TC[Scopus]:35  IF:14.6/16.8 | Submit date：2021/03/02
Autophagy  Cdk4  Cdk7  Phosphoproteomics  Protein Kinase  Silica Nanoparticles  
Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation Journal article
Ren, Yi, Chen, Jiaqing, Chen, Peishi, Hao, Qi, Cheong, Leng Kuan, Tang, Mingzhu, Hong, Lian Lian, Hu, Xuan Yu, Celestial T Yap,, Bay, Boon Huat, Ling, Zhi Qiang, Shen, Han Ming. Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2021, 166, 128-139.
Authors:  Ren, Yi;  Chen, Jiaqing;  Chen, Peishi;  Hao, Qi;  Cheong, Leng Kuan; et al.
Favorite | TC[WOS]:18 TC[Scopus]:18  IF:7.1/7.9 | Submit date：2021/11/30
Amp-activated Protein Kinase  Glucose Starvation  Liver Kinase B1  Non-small Cell Lung Cancer  Reactive Oxygen Species